put into a 500 ml flask along with a solution made up of 150 ml ethyl
alcohol, 150 ml water, and 100 grams KOH. Next, 15 ml of hydrazine
hydrate is added. This hydrazine should be the monohydrate, which is
64% hydrazine. If a weaker variety has been scrounged up, this can be
made to work by adding more, and using less water.
Now the flask should be fitted with a condenser, and flushed with
nitrogen. Then heat the flask in an oil bath to gentle boiling for 4
hours. A slow stream of nitrogen to the flask during the reflux averts
the danger from hydrazine.
The flask is next cooled, and the contents poured into a sep funnel of
at least 1000 ml capacity. The batch is then extracted with 600 ml
ether, followed by 600 ml of an 85-15% mix of ether and alcohol.
Finally, one more extraction with 600 ml of 85-15% ether-alcohol is
All of the desired product should now be extracted into the
solvent, and out of the water. This fact should be checked using a
black light to look for the characteristic blue fluorescence.
The combined solvent extracts should now be lowered to a pH of
about 2 using HC1. At this point, a precipitate should form, and it
should be filtered out. The precipitate should be washed free of
entrained product with 4-1 ether-alcohol, and the washing added to
the rest of the filtered solvent.
Now 2750 ml of water should be added to the solvent, and the
mixture placed in a gallon and a half glass jug or 5000 ml beaker. To
this should be added 3 portions of cation exchange resin in H* cycle.
Cation exchange resin is a common item of commerce used in
deionized water systems. Check the yellow pages under "water" and
see which of the local Culligan men offer deionized water systems.
The deionizers come in two-tank systems with one tank packed with
cation exchange resin to remove calcium, magnesium and sodium
from the water. The other tank has an anion exchange resin to remove
chlorides, sulfates, and so on. It is no great task to buy cation
exchange resin from these outlets. The resin consists of tiny plastic
beads coated with the exchanger. In the case of the cation exchangers,
Practical LSD Manufacture
this is generally a sulfonate. "In H* cycle" means that the resin is
charged up and ready to go. This is generally done by soaking the
resin in 20% sulfuric acid in water for a while, then rinsing with
distilled water. Check the directions on the container of resin. Steer
clear of mixed resins that contain both anion and cation exchangers. If
the Culligan man is too stupid to know the difference, or doesn't
know what he has, keep looking until you find one who knows his
The treatment with three portions of cation exchange resin in H*
cycle should be done as follows: Each portion of resin should weigh
about 15 grams. The first portion is added, and then the mixture
should be stirred strongly or shaken for about 10 minutes. The product
will come out of the liquid, and stick
ayahuasca medicine school Pillenliste School School Medicine
the alumina, two zones that fluoresce blue can be spotted by
illumination with a black light.
The faster-moving zone contains LSD,
while the slower-moving zone is iso-LSD.
When the zone containing LSD reaches the spigot of the burette, it
should be collected
4-aco-dmt vendor in a separate flask. About 3000 ml of the 3-1
benzene-chloroform is required to get the LSD vendor vendor moved down the
chromatography column, and finally eluted.
The iso-LSD is then flushed from the column by switching the
solvent being fed into the top of the column to chloroform.
material is collected in a separate flask, and the solvent removed
under a vacuum. The residue is iso-LSD, and should be stored in the
freezer until conversion to LSD is undertaken. Directions for this are
also given in this chapter.
For the fraction containing the LSD, conversion to LSD tartrate
must be done to make it water soluble, improve its keeping
characteristics, and to allow crystallization. Tartaric acid has the
ability to react with two molecules of LSD. Use, then, of a 50% excess of
tartaric acid dictates the use of about 1 gram of tartaric acid to 3
grams of LSD. The three grams of LSD would be expected from a
well-done batch out of a total 3.5 LSD/iso-LSD mix.
The crystalline tartrate is made by dissolving one gram of tartaric
acid in a few mis of methanol, and adding this acid solution to the
benzene-chloroform elute from the chromatography column.
Evaporation of the solvent to a low volume under a vacuum gives
crystalline LSD tartrate. Crystals are often difficult to obtain. Instead,
an oil may result due to the presence of impurities. This is not cause
for alarm; the oil is still likely 90%+ pure. It should be bottled up in
dark glass, preferably under a nitrogen atmosphere, and kept in a
freezer until moved.
If chromatography reveals that one's chosen cooking method
produces little of the iso products, then the production of the tartrate
salt and crystallization is simplified. The residue obtained at the end
Practical LSD Manufacture
of the batch is dissolved in a minimum amount of methanol. To this is
4-aco-dmt vendor tartaric acid. The same amount is added as above: one gram
tartaric acid to three grams LSD. Next, ether is slowly added with
vigorous stirring until a precipitate begins to form. The stoppered flask is
then put in the freezer overnight to complete the precipitation. After
filtering or centrifuging to isolate the product, it is transferred to a dark
bottle, preferably under nitrogen, and kept in the freezer until moved.
LSD from (so-LSD
Two variations on this procedure will be presented here. The first is
the method of Smith and Timmis from The Journal of the
Chemistry Society Volume 139, H pages 1168-1169 (1936).
The other is
found in US patent 2,736,728.
Both use the action of a strong
hydroxide solution to convert iso material into a mixture that contains
active and iso material. At equilibrium, the mixture contains about 2/3
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5 Other drugs 1
Premium Mimosa Hostilis Root Bark Pillenliste Xsekse
Premium Mimosa Hostilis Root Bark ing in the cold before then adding 25 ml of diethylamine.
Stir for an additional 10 minutes, then pour the batch into a 2000
ml sep funnel. Now to the sep funnel add 800 ml of water. Mix this in
thoroughly, then add 400 ml of saturated salt solution in water. Mix
this in, then extract out the LSD by repeated extraction with 250 ml
portions of ethylene dichloride. Check with a blacklight for complete
6 LSD From Lysergic Acid And SO3
The combined ethylene dichloride extracts should be evaporated
under a vacuum as above, and the residue of LSD and iso-LSD should be
separated and treated as above.
LSD From Lysergic Acid And
LSD From Lysergic Acid
And Trifluoroacetic Anhydride
This method is a little bit lame, but it may be the method of choice if
trifluoroacetic anhydride or trifluoroacetic acid should happen to fall
from the sky into one's hands. The reason why this method is a bit lame
is threefold. Anhydrous lysergic acid is required for this reaction. To
obtain anhydrous lysergic acid, the lysergic acid hydrate yielded by the
methods in Chapter 5 must be baked under high vacuum for a
couple hours. This is obviously not good for such a delicate molecule.
The water molecule will be shed by a baking temperature of 120° C at a
vacuum of 1 mm Hg, 140° C at 2 mm Hg, and still higher
temperatures at less perfect vacuums. A MacLeod gauge is the only
instrument that I know of which is capable of accurately measuring
such high vacuums.
Another reason why this method is lacking is that the yields are
not so good as those achieved by the other synthetic routes presented in
this book. It is possible to recover the unreacted lysergic acid at the end
of the process, but this does not make up for the initial lower yield,
not to mention the added hassle of recovering and redrying the lysergic
Strike number three for this route is its propensity to give byproducts
that are difficult to separate from the desired product. I am
Practical LSD Manufacture
not talking here about the large amount of iso-LSD that this method
makes. That molecular jumbling is inconsequential, because the
lysergic acid used is itself an isomeric mixture. Rather, what can
occur here is the production of LSD and other by-products.
The mechanics of this reaction are similar to the reaction with
SOs, in that two molecules of the anhydride react with the lysergic
acid molecule to form the mixed anhydride. In this reaction, there is
no need to first react the lysergic acid with hydroxide to form the
metal salt. Also, the need to follow exact stoichiometric quantities of
reactants is not as pressing as in the SO$ method.
To do the reaction, into a 1000 ml flask (carefully dried and
equipped with a magnetic stirring bar) place 16 grams of lysergic acid
and 375 ml of acetonitrile. The lysergic acid will not dissolve. Stopper
the flask and place it in the freezer to cool the contents to -20f Pillenliste
@Tuesday, September 25, 2018 5:14:37 PM