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there is decent drainage.
Cacti tend to grow mostly during spring and autumn, to send down roots in the
summer, and to rest through winter. Although cactus cuttings may be planted
anytime of the year they stand the best chance if planted in the late spring. They
should be watered thoroughly once or twice a week depending upon how rapidly
moisture is lost. The soil an inch below the surface should always contain some
moisture. Watering can be cut back to less than half during the winter.
INCREASING THE POTENCY OF PSYCHOACTIVE CACTI There are several
factors which influence production of mescaline and related alkaloids in cacti.
Presence of a wide variety of trace minerals is important. Occasional watering
with Hoagland A-Z trace mineral concentrate provides these minerals. Combine
1 part concentrate with 9 parts water and water cacti with this once every two
Experiments conducted by Rosenberg, Mclaughlin and Paul at the University of
of Michigan, Ann Arbor in 1966 demonstrated that dopamine is a precursor of
mescaline in the peyote cactus. Tyramine and dopa were also found to be
mescaline precursors, but not as immediate and efficient as dopamine. It
appears that in the plant tyosine breaks down to become tyramine and dopa.
These then recombine to form dopamine which is converted to nor-mescaline
and finally to mescaline. One can take advantage to this sequence by inject-ing
each peyote plant with dopamine 4 weeks prior to harvesting. Much of the
dopamine will convert to mescaline during this time, giving a considerable
increase in the alkaloid of the plant. Prepare a saturated solution of free base
dopamine in a .05 N solution of hydrochloric acid and inject 1-2 cc into the root of
each plant and the same amount into the green portion above the root. Let the
needle penetrate to the center of the plant, inject slowly and allow the needle to
remain in place a few seconds after injection. It is best to deprive the plant of
water for 1-2 weeks before injection. This makes the plant tissues take up the
injection fluids more readily. If dopamine is not available, a mixture of tyramine
and dopa can be used instead 6 weeks before harvesting for comparable results.
San Pedro and other mescaline-bearing cacti can be similarly treated for
increased mescaline production. Inject at the base of the plant and again every
3-4 inches following a spiral pattern up the length of the plant. A series of booster
injections can be given to any of these cacti every 6-8 weeks and once again 4
weeks before harvesting for greater mescaline accumulation.
It is also possible to increase the macromerine and nor-macromerine content of
Doñana cacti using tyramine or DL-norepinephrine as precursors. Injections
should be given 20-25 days before harvesting. Series of injections can be given
45 days apart for higher alkaloid accumulation.
EXTRACTING PURE MESCALINE FROM PEYOTE OR SAN PEDRO
The isolation of mescaline from cacti
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the empty jug with 100 ml of ether to salvage
any crystals in the jug and pour the ether over the crystals in the filter.
ether has passed through the filter repeat the rinsing with another 100 ml of
Then let the crystals dry. If ether is not available or you do not wish to use
such a highly combustible substance, the precipitate and residual benzene can
be poured into a beaker. The jug should be rinsed several more times with a little
benzene and added to the beaker so no crystals are left behind. The beaker is
then placed in a heat bath until all of the benzene has been evaporated.
The next step is to purify the mescaline sulfate crystals. Dissolve the dry crystals
in 200 ml of near-boiling distilled water. Add a pinch of activated charcoal (Norite)
and filter while still hot through number 2 filter paper. The hot water which
contains the mescaline will pass through the filter. The Norite absorbes impurities
from the mescaline.
After the liquids Buy4acodmt have passed through the filter pour a little
more hot water over the filter to rinse through any remaining mescaline which
may have impregnated the filter paper. Add 10 percent ammonia solution a few
drops at a time to the hot filtrates until the solution registers between pH 6.5 and
Place a boiling stone in the solution and reduce it's volume to 75 ml by boiling.
Remove the boiling stone and allow the solution to cool to room temperature.
Place the solution in a freezer or in a refrigerator set to the coldest possible
temperature and allow the solution to cool to almost freezing. Tiny white needlelike
crystals form around the bottom and sides of the beaker. Break up the
crystals with a glass stirring rod while the solution is still ice cold and pour
through a filter. Mescaline sulfate is insoluable in near freezing water and will not
pass through the filter. Rinse the beaker with fresh ice water and pour this over
The crystals will now be pure white and can be dried under a heat lamp
or in an over at 250 degrees F. More mescaline can be salvaged from the water
that has passed through the filter
by boiling these liquids down to about 20 ml,
adding Norite while hot, filtering through number 2 paper as before, chilling the
filterate to near freezing as once before, filtering while cold, rinsing with ice water
and drying the crystals.
This repetition should obtain at least two more grams of
If large volume mescaline extraction is being conducted it
would be worthwhile to repeat this salvaging procedure several more times.
MIXED ALKALOID EXTRACTIONS
There are numerous methods for extracting a mixture of the alkaloids from cacti.
Different methods may result in varying degrees of purity. For example, the dried,
pulverized material can be defatted with petroleum ether or lighter fluid prior to
extraction to remove lipid content; solvent combinations such as
methanol/chloroform/ammonium hydroxide can be used for extracting;
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