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It is significant to note that neither one of these plant substances by itself is normally psychoactive in oral doses. (Harmine/harmaline is said to effect hallucinosis at highly toxic levels, but in less heroic quantities it is at best a tranquilizer, at worst an emetic.) DMT, in any quantity, is not orally active unless used in combination with a monoamine oxidase (MAO) inhibitor. This principle is precisely what makes ayahuasca effective; the harmala alkaloids in the Banisteriopsis caapi vine are potent short term MAO inhibitors which synergize with the DMT-containing Psychotria viridis leaves to produce what has been described as one of the most profound of all psychedelic experiences.
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