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there is decent drainage.
Cacti tend to grow mostly during spring and autumn, to send down roots in the
summer, and to rest through winter. Although cactus cuttings may be planted
anytime of the year they stand the best chance if planted in the late spring. They
should be watered thoroughly once or twice a week depending upon how rapidly
moisture is lost. The soil an inch below the surface should always contain some
moisture. Watering can be cut back to less than half during the winter.
INCREASING THE POTENCY OF PSYCHOACTIVE CACTI There are several
factors which influence production of mescaline and related alkaloids in cacti.
Presence of a wide variety of trace minerals is important. Occasional watering
with Hoagland A-Z trace mineral concentrate provides these minerals. Combine
1 part concentrate with 9 parts water and water cacti with this once every two
Experiments conducted by Rosenberg, Mclaughlin and Paul at the University of
of Michigan, Ann Arbor in 1966 demonstrated that dopamine is a precursor of
mescaline in the peyote cactus. Tyramine and dopa were also found to be
mescaline precursors, but not as immediate and efficient as dopamine. It
appears that in the plant tyosine breaks down to become tyramine and dopa.
These then recombine to form dopamine which is converted to nor-mescaline
and finally to mescaline. One can take advantage to this sequence by inject-ing
each peyote plant with dopamine 4 weeks prior to harvesting. Much of the
dopamine will convert to mescaline during this time, giving a considerable
increase in the alkaloid of the plant. Prepare a saturated solution of free base
dopamine in a .05 N solution of hydrochloric acid and inject 1-2 cc into the root of
each plant and the same amount into the green portion above the root. Let the
needle penetrate to the center of the plant, inject slowly and allow the needle to
remain in place a few seconds after injection. It is best to deprive the plant of
water for 1-2 weeks before injection. This makes the plant tissues take up the
injection fluids more readily. If dopamine is not available, a mixture of tyramine
and dopa can be used instead 6 weeks before harvesting for comparable results.
San Pedro and other mescaline-bearing cacti can be similarly treated for
increased mescaline production. Inject at the base of the plant and again every
3-4 inches following a spiral pattern up the length of the plant. A series of booster
injections can be given to any of these cacti every 6-8 weeks and once again 4
weeks before harvesting for greater mescaline accumulation.
It is also possible to increase the macromerine and nor-macromerine content of
Doñana cacti using tyramine or DL-norepinephrine as precursors. Injections
should be given 20-25 days before harvesting. Series of injections can be given
45 days apart for higher alkaloid accumulation.
EXTRACTING PURE MESCALINE FROM PEYOTE OR SAN PEDRO
The isolation of mescaline from cacti
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into the benzene during separation pour everything back into the separator, let it
stand and repeat the separation more carefully. It is better to leave some
benzene layer in the water and emulsion than to get emulsion and water into the
benzene. Nothing will be wasted. All of the benzene which contains the
mescaline will eventually be salvaged. Sometimes the layers will fail to separate
properly. If this is the case immerse the funnel or jug in a deep pot of hot water
for two hours. This will break up the emulsion and bring about the separation.
Prepare a solution of 2 parts sulfuric acid and one part water. (never add water to
the acid or it will splatter; add the acid a little at a time to the water by pouring it
down the inside of the graduate or measuring cup containing the water.) Add 25
drops of the acid solution one drop at a time to the benzene extracts. Stopper the
jug and shake well for one minute. Then let stand for five minutes. White streaks
of mescaline sulfates should begin to appear in the benzene. If these do not
appear, shake the jug more vigorously for two to three minutes and let it settle for
five more minutes. I have found that when extracting mescaline from San Pedro
it is sometimes necessary to shake the mixture more thoroughly and for a longer
time to get the mescaline streaks to form. This is probably because of the lower
mescaline content in the plant. This would also apply to any peyote that does not
have a high mescaline content. After the streaks appear add 25 more drops of
the acid solution in the same manner, shake as before and let settle for ten
minutes. More streaks will appear. Add 15 drops of acid, shake and wait 15
minutes for streaks to form. Add 10 drops, shake and wait about 30 minutes.
Test the solution with wide range pH paper. It should show that the solution is
between pH 7.5 and 8. Allow the mescaline sulfate crystals to completely
precipitate. Siphon off as much of the benzene as possible without disturbing the
crystals on the bottom of the jug.
The next steps are to salvage any mescaline still in the water and emulsion layer.
Combine the benzene siphonings with the water/emulsion layer, shake these well
together for 5 minutes and let settle for two hours as before. Carefully remove the
benzene layer, treat it again with acid, precipitate the crystals and siphon off the
benzene as in the previous steps. Recombine the siphoned benzene with the
watery layer and repeat this again and again until no more crystals precipitate.
Siphon off as much benzene as possible without drawing crystals through the
The next step involves removing the remaining benzene from the crystals. There
are two methods to choose from. The first is the quickest, but requires ether,
which is dangerous and often difficult to procure. Shake up the crystals with the
remaining benzene and pour it into a funnel with filter paper. After the benzene
has passed through the filter rinse Leaf
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