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erature reading lesson to those who
have made these claims. See Proceedings of the Royal Society of
London, Series B, Volume 155, pages 26 to 54 (1961).
Also see US
Patent 3,219,545. You will note while reading these articles detailing
how to get lysergic amide production in a culture medium that these
guys had to scour the globe to find that rare strain of claviceps fungus
that will cooperate in this manner.
The vast majority of claviceps
fungi just will not produce these alkaloids while being cultured. See
the following articles to convince yourself of just how futile it is to
collect a wild strain of claviceps and try to get it to produce lysergic
acid amides in culture: Ann. Rep. Takeda Res. Lab Volume 10, page 73
(1951); and Farmco, Volume 1, page 1 (1946); also Arch. Pharm. Berl.
Volume 273, page 348 (1935); also American Journal of
Practical LSD Manufacture
Botany, Volume 18, page 50 (1931); also Journal of the American
Pharmacy Association Volume 40, page 434 (1951); also US patent
2,809,920; also Canadian Journal of Microbiology, Volume 3, page
55 (1957), and Volume 4, page 611 (1958) and Volume 6, page 355
(1960); also Journal of the American Pharmacy Society Volume 44,
page 736 (1955).
With this matter disposed of, it is time to move on to what
actually are viable sources of lysergic acid amides for the production of
This is the farming end of the acid business. It is only through
raising ergot-infested rye, or growing morning glories and Hawaiian
baby woodrose that the required feedstocks of lysergic compounds
can be obtained without making a target of oneself. I have for years
seen ads in High Times offering morning glory seeds and Hawaiian
baby woodrose seeds for sale, but these are offered in small amounts at
I would bet my bottom dollar that these outfits, if they are
not front operations, will at least report to the heat any large orders they
To avoid detection, the aspiring LSD manufacturer must be ready
to get his hands dirty, and spend some time as a farmer.
The most difficult farming choice, and as luck would have it, the
one that gives the purest acid, is to grow a patch of ergot-infested rye.
The reason why ergot is superior to growing morning glory seeds or
woodrose seeds is Legaldmtsources that these seeds have a considerable amount of
another type of alkaloid in them besides the ones that yield lysergic
acid. These other alkaloids are of the clavine type, meaning that they
have the lysergic-acid skeleton, but lack the carboxyl grouping. In its
place will be a methyl grouping, an alcohol grouping, a methyl
alcohol grouping or combinations of the above. These clavine
alkaloids will likely be carried all the way through into the product,
producing both the GIGO situation during the synthetic operations
and a contaminated product when finished.
I will present my ideas on
how to remove them, but they are best avoided in the first place.
Ergot is the name given to a dark brow
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Cacti tend to grow mostly during spring and autumn, to send down roots in the
summer, and to rest through winter. Although cactus cuttings may be planted
anytime of the year they stand the best chance if planted in the late spring. They
should be watered thoroughly once or twice a week depending upon how rapidly
moisture is lost. The soil an inch below the surface should always contain some
moisture. Watering can be cut back to less than half during the winter.
INCREASING THE POTENCY OF PSYCHOACTIVE CACTI There are several
factors which influence production of mescaline and related alkaloids in cacti.
Presence of a wide variety of trace minerals is important. Occasional watering
with Hoagland A-Z trace mineral concentrate provides these minerals. Combine
1 part concentrate with 9 parts water and water cacti with this once every two
Experiments conducted by Rosenberg, Mclaughlin and Paul at the University of
of Michigan, Ann Arbor in 1966 demonstrated that dopamine is a precursor of
mescaline in the peyote cactus. Tyramine and dopa were also found to be
mescaline precursors, but not as immediate and efficient as dopamine. It
appears that in the plant tyosine breaks down to become tyramine and dopa.
These then recombine to form dopamine which is converted to nor-mescaline
and finally to mescaline. One can take advantage to this sequence by inject-ing
each peyote plant with dopamine 4 weeks prior to harvesting. Much of the
dopamine will convert to mescaline during this time, giving a considerable
increase in the alkaloid of the plant. Prepare a saturated solution of free base
dopamine in a .05 N solution of hydrochloric acid and inject 1-2 cc into the root of
each plant and the same amount into the green portion above the root. Let the
needle penetrate to the center of the plant, inject slowly and allow the needle to
remain in place a few seconds after injection. It is best to deprive the plant of
water for 1-2 weeks before injection. This makes the plant tissues take up the
injection fluids more readily. If dopamine is not available, a mixture of tyramine
and dopa can be used instead 6 weeks before harvesting for comparable results.
San Pedro and other mescaline-bearing cacti can be similarly treated for
increased mescaline production. Inject at the base of the plant and again every
3-4 inches following a spiral pattern up the length of the plant. A series of booster
injections can be given to any of these cacti every 6-8 weeks and once again 4
weeks before harvesting for greater mescaline accumulation.
It is also possible to increase the macromerine and nor-macromerine content of
Doñana cacti using tyramine or DL-norepinephrine as precursors. Injections
should be given 20-25 days before harvesting. Series of injections can be given
45 days apart for higher alkaloid accumulation.
EXTRACTING PURE MESCALINE FROM PEYOTE OR SAN PEDRO
The isolation of mescaline from cacti
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